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KMID : 0880220120500010149
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Journal of Microbiology
2012 Volume.50 No. 1 p.149 ~ p.154
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Neutralization potential of the plasma of HIV-1 infected Indian patients in the context of anti-V3 antibody content and antiretroviral theraphy
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Alok Kumar Choudhary
Raiees Andrabi
Somi Sankaran Prakash
Rajesh Kumar
Shubhasree Dutta Choudhury
Kalpana Luthra
Ashutosh Biswas
Naveet Wig
Anjali Hazarika
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Abstract
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We assessed the anti-V3 antibody content and viral neutralization potential of the plasma of 63 HIV-1-infected patients (antiretroviral naive=39, treated=24) against four primary isolates (PIs) of clade C and a tier 1 clade B isolate SF162. Depletion and inhibition of anti-V3 antibodies in the plasma of five patients with high titers of anti-V3 antibodies led to modest change in the neutralization percentage against two PIs (range 0?21%). The plasma of antiretroviral-treated patients exhibited higher neutralization potential than that of the drug-naive plasmas against the four PIs tested which was further evidenced by a follow-up study.
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KEYWORD
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HIV-1, India, neutralizing antibodies, anti-V3 antibodies, antiretroviral therapy
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